Current Issue : July-September Volume : 2010 Issue Number : 3 Articles : 1 Articles
Met-H is an antidiabetic drug, used in the treatment of type 2 diabetes (non-insulin dependent diabetes mellitus). Met-H is a highly water soluble drug with a short biological half life of 1.5-3 hrs and is eliminated rapidly from the body. Repeated daily administrations are required to maintain effective plasma concentration. It shows a low and irregular bioavailability of about 50 to 60% after oral administration. In the present study, preparation of Met-H microspheres, prediction of the release, and optimization of entrapment efficiency, and drug release to match the target release profile which was investigated. Microspheres were prepared by nonaqueous solvent evaporation technique using hydrophobic polymer i.e. ethyl cellulose and hydrophilic polymer hydroxy propyl methyl cellulose K15M.The major advantage of the preparation technique includes, short processing time, lack of exposure of ingredients to high temperature, and high encapsulation efficiency. Formulations were prepared by using various ratios of drug: ethyl cellulose:hydroxyl propyl methyl cellulose K15M and were evaluated by usual pharmacopoeial methods and other tests such as drug-polymer compatibility (IR scan and DSC), yield (%), particle size analysis, drug entrapment efficiency, surface topology, and in-vitro drug release studies. Results showed that the different ratios of components in the organic phase affected the size of microspheres, size distribution (466-490 �µm), entrapment efficiency (83.64 % to 68.95 %), % yield (74.27% to 75.41%) and the drug release of microspheres (55% to 97% after 10 hrs), and the best results were obtained at the ratio of drug: ethyl cellulose: hydroxyl propyl methyl cellulose K15M (1:1.25:0.75). In most cases wide range of drug release pattern could be achieved by variation of polymer ratio, which was optimized to make target release profile....
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